The week-long event, which has been slated to end on Thursday next week, involves four teams with a view to improving the standard of female cricketers in the continent.
Namibia, Uganda and hosts Zimbabwe are the other sides that will battle it out in the tournament.
The opening match has been slated to take place at the field A of the Old Hararians venue and three other matches will as well be played at the venue later in the day.
The day's second match will pit Namibia against Uganda at the field B of the venue and the third match which will see the former face Zimbabwe, will be held at the field A.
Fatuma Omary, an experienced member of the squad, had earlier revealed she is optimistic over the squad’s chances to excel in the competition.
The squad’s participation in the Asean Women’s T20 Championship, which took place in Thailand from March 7 to 13, she disclosed, helped the team shape up well for the Zimbabwe Women’s T20 Challenge.
“The competition boosted our confidence given we played different foreign opponents and I’m optimistic we will excel in the Zimbabwe Women’s Challenge,” Fatuma said.
Uganda ladies will then lock horns with Tanzania in the day's last match at the field A of the Old Hararians venue.
All of the participating sides will have a rest on Monday and the next day will see Namibia play Tanzania in the first match at the field A in the morning.
In the next two matches, the hosts will lock horns with Uganda and Tanzania at the fields B and A respectively.
Uganda will confront Namibia in the last match of the day at the field B.
Wednesday's first match will see Zimbabwe on Uganda at the field A in the morning, to be followed by the match between Tanzania and Namibia at the field B.
Zimbabwe women outfit will again be in action in the afternoon as the side will confront Namibia at the field A, whereas the day's last match will pit Uganda against Tanzania at the field B.
The tournament's third and fourth places' play off will take place at the Takashinga venue in the morning and the final will be held at the same venue in the afternoon.
Fourteen players, who make Tanzania women team, and three officials, travel to Zimbabwe tomorrow for the tournament.