If City win the game it will be their 14th league victory in a row - a record in a single Premier League season.
However, Guardiola says his focus is only on developing a strategy to beat Jose Mourinho's side.
"The record will be broken, my concern is how we win the game," he said.
"If you play one game thinking about records you forget what you have to do."
This is the first derby since April 2013 where the two clubs occupy the top two positions in the table.
If City win at Old Trafford they will move 11 points clear while United would close the gap to five with victory.
Guardiola believes it is far too early to suggest the match could be a title decider.
"Winning, drawing or losing on Sunday, we are not going to win or lose the Premier League. It's December," he added.
"There are a lot of points to play for, more than 70. We just focus on the game."
Guardiola and Mourinho have a long-running rivalry, stretching back to their time in Spain as managers of Barcelona and Real Madrid respectively.
That rivalry has, at times, been feisty but Guardiola believes when it comes to the desire to win trophies they are the same.
"Definitely. In that we are twins," said Guardiola when asked if he was as obsessed with winning as Mourinho.
"They want to win trophies, we want to win trophies. I think [Chelsea boss] Antonio Conte is the same as well, and [Liverpool manager] Jurgen Klopp and [Tottenham boss] Mauricio Pochettino, and in all the leagues around the world, the managers are like that.”